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Page 721 IgG4-related disease (RD) is a newly recognized systemic disease characterized by high serum IgG4 levels that affects multiple organs including salivary glands and the nasal and paranasal sinuses. Accordingly, many IgG4-RD patients complain about olfactory dysfunction. Yagi-Nakanishi et al have now investigated olfactory function in these patients. More than 50% of the patients suffered from olfactory dysfunction for non-obvious reasons whereas they did not differ from the other patients in clinical features. Biopsies from the inferior turbinate revealed no correlation between olfactory score and number of IgG4-positive cells. This finding obscures the mechanism linking olfactory dysfunction to IgG4-RD. Out of six patients studied one recovered from hyposmia to normal spontaneously as the IgG4 levels normalized. Five did so after medication with corticosteroid. Thus, whereas olfactory dysfunction appears to be a frequent and important manifestation of IgG4-RD it can be reversed.